Left Atrial Appendage Closure vs. Oral Anticoagulation in Patients With Atrial Fibrillation: An Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials.

J Arrhythm · 2026 · PMC13282471 · PMID 42328186

Europe PMC DOI

hedged sentences

0.5000

closest p · 10.0× alpha

0.5000

boldest claim

The sentences

did not reach statistical significancep = 0.50not close (p > 0.1)

Although a 23% relative risk reduction was observed for the composite endpoint of stroke, systemic embolism, or death from cardiovascular or unexplained causes, this did not reach statistical significance, with the upper bound of the confidence interval approaching 1 (RR 0.77, 95% CI 0.59–1.00; p = 0.50; I 2 = 0%; Figure 3 ), suggesting the need for further evidence to validate this trend.

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borderline significantno p-value reported

For the composite endpoint of stroke, systemic embolism, or cardiovascular/unexplained/all‐cause mortality, a borderline significant reduction was found with LAAC, with no heterogeneity (I 2 = 0%) across 1736 LAAC recipients and 1380 controls.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.