Defining the Human Nucleus Pulposus Microenvironment and Its Impact on Cell Matrix Synthesis and Metabolic Activity.

JOR Spine · 2026 · PMC13282693 · PMID 42327385

Europe PMC DOI

hedged sentences

0.0570

closest p · 1.1× alpha

0.0759

boldest claim

The sentences

showed a trendp = 0.057so close (0.05 < p ≤ 0.1)

TNF‐α showed a trend toward increased levels between Pfirrmann grades 3 and 4 ( p = 0.057).

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an increasing trendp = 0.0759so close (0.05 < p ≤ 0.1)

VEGF demonstrated an increasing trend when stratified histologically between grades with higher mean fluorescence intensity (MFI) observed between histological grades 0–3 to 7–9 ( p = 0.0759) and grades 4–6 to 7–9 ( p = 0.0832).

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