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CD109 Drives Stemness and Chemoresistance in Colorectal Cancer via LRRC8A/AKAP12/PKCα-Mediated STAT3 Activation and WNT Signaling.

Int J Biol Sci · 2026 · PMC13282776 · PMID 42328435

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S7 A, B ), whereas in SW620 cells, although both CD109 and LRRC8A knockdown decreased the amplitude of hypotonicity-induced currents, such reduction did not reach statistical significance for LRRC8A-targeting siRNA, most likely because of the high variability of the response ( Fig.

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