Prospects for Neuroprotective Therapies in Glaucoma: Drug Targets and Emerging Clinical Strategies.

A study by Parisi et al showed that topical citicoline eye drops, which reach the retina through vitreous bioavailability, produced positive trends in visual field indices in individual eyes, though group-level changes did not reach statistical significance; electrophysiologically, PERG showed reduced P50 latency, and increased P50-N95 amplitude, suggesting enhanced RGC function. 83 Oral citicoline at 250 mg/day in a 54-patient study produced a significant increase in average RNFL thickness at 3 months (notably in average and inferior quadrants), though effects partially regressed after washout, with no significant macular ganglion cell-inner plexiform layer (mGCIPL) changes.

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