Prognostic significance of KRAS G12C versus non-G12C RAS mutations in metastatic colorectal cancer: a systematic review and meta-analysis.

Oncologist · 2026 · PMC13283479 · PMID 42231123

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did not reach statistical significanceno p-value reported

While the pooled mOS difference approached but did not reach statistical significance, the significant mPFS difference and the significant pooled HR = 1.28 together provide convergent evidence of worse outcomes for KRAS G12C patients.

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