Integrative multi-omics analysis identifies a robust 14-metabolite signature and reveals microbiome-metabolite-host interactions in atherosclerosis.

As shown in Supplementary Figure S1A , the mRNA expression levels of P65 and Caspase-1 were higher in the AS group compared with HC, although these differences did not reach statistical significance (both P > 0.05), indicating limited alteration of classical inflammatory signaling in circulating PBMCs in this cohort.

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