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Acute and 14-day effects of tiotropium/olodaterol on cardiopulmonary function in COPD.

ERJ Open Res · 2026 · PMC13284810 · PMID 42338678

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showed a trendno p-value reported
Again, the breakdown of comparisons to baseline showed a trend towards a slight decrease after placebo administration (−0.38 mL·m −2 ; 95% CI −2.68 to 1.92), while after single-dose T/O administration an increase was observed (1.89 mL·m −2 ; 95% CI −0.45 to 4.22), only reaching the significance threshold after multiple-dose T/O administration (4.09 mL·m −2 ; 95% CI 2.31 to 5.88).

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