Cetirizine suppresses cancer-associated fibroblast-mediated fibrotic remodeling and epithelial-mesenchymal transition via histamine H<sub>1</sub> receptor inverse agonism.

In a separate experiment, when cetirizine administration was initiated immediately after tumor implantation, survival tended to be prolonged compared with controls, although the difference did not reach statistical significance (Fig. 2 C).

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