Potential oncogenic role of occult hepatitis B virus pre-S mutations: Activation of Akt/mTOR/Cyclin D1 signaling drives cell cycle dysregulation and proliferation in hepatocellular carcinogenesis.

Genes Dis · 2026 · PMC13285653 · PMID 42339204

Europe PMC DOI

hedged sentence

—

closest p

—

boldest claim

The sentences

did not reach statistical significanceno p-value reported

At the transcriptional level, the mutations significantly elevated Cyclin D1 mRNA levels, although the increase induced by the N98T mutation did not reach statistical significance ( Fig. 3 C).

also in 111,027 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.