Direct oral anticoagulants in portal vein thrombosis in patients with cirrhosis: a systematic review and meta-analysis.

Blood Adv · 2026 · PMC13285837 · PMID 41985012

Europe PMC DOI

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0.1000

closest p · 2.0× alpha

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boldest claim

The sentences

did not reach statistical significanceP = .10so close (0.05 < p ≤ 0.1)

In the pooled random-effects analysis, DOAC therapy showed a numerically higher rate of partial recanalization, although the difference did not reach statistical significance (RR, 2.12; 95% CI, 0.87-5.16; P = .10).

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a nonsignificant trendno p-value reported

Studies restricted to Child-Pugh A/B only (no C) In studies including only Child-Pugh A or B patients, 17 , 22 DOAC therapy was associated with a significantly higher rate of complete PVT recanalization compared with VKAs (RR, 3.50; 95% CI, 2.04-6.00; I 2 = 0%), and a nonsignificant trend toward higher rates of partial PVT recanalization compared with VKAs (RR, 2.00; 95% CI, 0.78-5.14; I 2 = 0%).

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