Clinical, hemodynamic, and safety outcomes of sotatercept in pulmonary arterial hypertension: a meta-analysis of randomized trials with time-to-event data.

Ther Adv Respir Dis · 2026 · PMC13287412 · PMID 42312805

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a favorable trendno p-value reported

Although mortality benefits remain inconclusive, a favorable trend was observed.

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did not reach statistical significanceno p-value reported

Our meta-analysis showed about a 77% lower risk of composite clinical worsening) and roughly 40 extra weeks of event-free survival, while all-cause mortality trended lower but did not reach statistical significance.

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