α7nAChR agonist GTS-21 ameliorates sepsis-induced acute kidney injury via MEF2/PGC-1α/HO-1 axis in mice.

Clin Transl Med · 2026 · PMC13287963 · PMID 42333777

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did not reach statistical significanceno p-value reported

First, although GTS‐21 significantly attenuated renal injury, mitochondrial dysfunction, apoptosis and systemic inflammatory responses in CLP‐induced S‐AKI, the improvement in survival did not reach statistical significance.

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highly significantno p-value reported

p < .05 was considered statistically significant, and p < .01 was considered highly significant.

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