A caffeic acid-loaded hydrogel attenuates inflammation and accelerates infected wound healing.

Front Bioeng Biotechnol · 2026 · PMC13290853 · PMID 42358444

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highly significantno p-value reported

A value of p < 0.05 was considered statistically significant, and p < 0.01 was considered highly significant. 3 Results 3.1 Preparation and characterization of H(CODEX) and H(CODEXC) hydrogels In this study, double-network hydrogels were prepared from methacrylated carboxymethyl chitosan (CMCSMA) and oxidized dextran (ODex) through free-radical polymerization and Schiff base formation.

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did not reach statistical significanceno p-value reported

By day 9, the wound area in the H(CODEXC) group had decreased to 14.4% of the initial area, compared with 27.8% in the control group and 28.0% in the H(CODEX) group; however, these intergroup differences did not reach statistical significance.

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