HCN4 gain-of-function mutation increases intrinsic heart rate and limits maladaptive remodeling under pressure overload.

Front Pharmacol · 2026 · PMC13291042 · PMID 42358349

Europe PMC DOI

hedged sentence

0.0550

closest p · 1.1× alpha

0.0550

boldest claim

The sentences

did not reach statistical significancep = 0.055so close (0.05 < p ≤ 0.1)

Intracellular application of a saturating cAMP concentration induced an additional rightward shift of ∼7 mV in HCN4F cells, which did not reach statistical significance (p = 0.055), whereas WT cells exhibited a significant ∼10 mV shift.

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