Pro-regenerative fingerprints identified in a sub-population of adult mouse cardiomyocytes by integrative single-cell proteomics.

Among the studied compartments, endoplasmic reticulum, sarcomere, ribosome, nucleus and cytoskeleton showed a trend to increase in Myc-overexpressing with respect to control cardiomyocytes, whereas the secreted, golgi, extracellular matrix (ECM) and cytosol compartments showed the opposite trend.

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We found that representative fatty acid oxidation-related proteins showed low- or non-significant changes when comparing both types of cells isolated by FACS; however, all these proteins showed highly significant changes when comparing manually isolated cells (Fig. 3 c and d).

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