Hippocampal neuroinflammation and altered peripheral neurobiological protein profile in experimental arthritis and systemic juvenile idiopathic arthritis.

43 , 44 , 45 We observed positive correlations between serum IL-6 and IL-18 levels (the correlation with IL-6 did not reach statistical significance) and microglial activation in the hippocampus in arthritic mice, indicating that elevated levels of these cytokines could be contributing factors to the central neuroinflammatory processes detected.

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