Common human ALDH1B1 and ALDH2 variants increase neuroinflammatory response to a single ethanol dose in mice.

Sci Adv · 2026 · PMC13292932 · PMID 42341106

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Furthermore, a comprehensive analysis of multiple cytokines in brain protein extracts of the four groups of mice showed a trend toward less increasing proinflammatory cytokines in ALDH1B1 G193fs mice compared to ALDH2 E504K mice and DKI mice ( Fig. 4C and figs.

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