Neuroplastic white matter changes in patients with major depression following lysergic acid diethylamide treatment.

Finally, we ran several analyses to study the effects of variation in time (i.e., days to scan) between the second intervention and the second scan: (i) an independent-samples t test demonstrated that the two groups did not differ in the duration between the second intervention and the second scan (t 33 = 0.01; p = 0.99); (ii) a regression analysis using the number of days to scan as a predictor for post-intervention FA indicated a trend toward significance across groups (F 1,33 = 3.76, p = 0.06), suggesting a possible relationship between changes in FA and time since treatment.

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Post-intervention FA values were significantly correlated with improvements in depressive symptoms at the primary endpoint (ΔIDS-C: R = −0.51, P adj = 0.04; Figure 3 A, left) and at the final follow-up (ΔIDS-C: R = −0.71, P adj = 0.004; Figure 3 C, left) and showed a trend toward significance at the first follow-up (ΔIDS-C: R = −0.53, P adj = 0.06; Figure 3 B, left) in the HD-LSD group only.

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