mRNA vaccination using peptide nanoparticles triggers a strong immune response against endogenous GPC2 in a murine neuroblastoma model.

Mol Ther Oncol · 2026 · PMC13293994 · PMID 42369018

Europe PMC DOI

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closest p · 0.0× alpha

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boldest claim

The sentences

highly significantp < 0.0001actually significant

Splenocytes from mice vaccinated intravenously with RALA/ mGPC2 produced highly significant levels of antigen-specific IFN-γ (107.1 SFU/250,000 cells ±18.65; p < 0.0001) and IL-2 (100.6 SFU/250,000 cells ±22.61; p < 0.001).

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showed a trendno p-value reported

Splenocytes isolated from RALA/ mGPC2 -vaccinated mice showed a trend toward increased TNF-α production by CD4 + and CD8 + T cells, levels higher than those in control groups ( Figures 3 C and 3D).

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