Mouse models to study von Willebrand factor in inflammation: a scoping review.

Studies administering recombinant ADAMTS13 after the onset of ischemia-reperfusion injury, endotoxemia, or organ injury consistently reported reductions in microvascular thrombosis, inflammatory cytokine levels, and organ damage scores,[ 67 , 96 , 98 , 117 , 127 ] whereas prophylactic administration was less uniformly beneficial and, in some models, did not reach statistical significance for primary outcomes [ 109 , 132 ].

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