Barely Significant
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Bone-Targeting Microspheres Enable Sustained Release of CD301b<sup>+</sup> Macrophage-Derived Small Extracellular Vesicles to Promote Bone Repair.

Theranostics · 2026 · PMC13295118 · PMID 42370173

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an increasing trendno p-value reported
Although eNOS expression also showed an increasing trend, the difference was not statistically significant compared with the A-SCH/OSA group. eNOS primarily functions to catalyze the production of nitric oxide, which is mainly involved in the maturation and functional stabilization of newly formed vessels 55 .

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The A-SCH/OSA group showed a tendency toward enhanced bone repair than the SCH/OSA group, but the differences did not reach statistical significance.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.