officinalis fruit juice at 1 mL/kg/day over 8 weeks in STZ-induced Wistar rats significantly reduced serum glucose and AUC glucose, though the serum insulin increase did not reach statistical significance [ 200 ].
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Polyphenol-Mediated Modulation of Oxidative Stress Pathways in Type 1 Diabetes: A Systematic Review.
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Silymarin similarly had mixed results, with administration at 40 and 80 mg/kg/day significantly reducing fed blood glucose at days 14 and 21 in STZ-induced albino mice, while the lower 20 mg/kg dose did not achieve significance, suggesting a dose threshold effect which was contrasted by the second silymarin study where 50 and 100 mg/kg/day over 30 days in alloxan-induced Fischer rats reported no significant reduction in serum glucose at either dose [ 89 , 90 ].