Artificial intelligence-guided analysis of the tumor microenvironment predicts response to pembrolizumab in rare tumors.

J Immunother Cancer · 2026 · PMC13295762 · PMID 42342409

Europe PMC DOI

hedged sentences

0.0820

closest p · 1.6× alpha

0.0840

boldest claim

The sentences

a trend toward significancep=0.082so close (0.05 < p ≤ 0.1)

In the overall cohort of analyzable specimens (n=83), there was only a trend toward significance for improved PFS in tumors with iTIL ≥60 cells/mm 2 (n=23; HR 0.62, 95% CI 0.37 to 1.06, p=0.082; figure 2C ).

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showed a trendp=0.084so close (0.05 < p ≤ 0.1)

In paired biopsies, on-treatment increase in iTIL showed a trend toward improved PFS (HR 0.64, 95% CI 0.40 to 1.06, p=0.084) and was significantly associated with improved OS (HR 0.55, 95% CI 0.35 to 1.01, p=0.037).

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a trend towards significancep=0.084so close (0.05 < p ≤ 0.1)

There was a trend towards significance suggesting that the same threshold indicated improved PFS (median 2.7 vs 2.0 months; HR 0.64, 95% CI 0.39 to 1.06, p=0.084; figure 3B ).

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