Barely Significant
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A Cross-Sectional Dual-Site Analysis of the Gastric Antral and Duodenal Mucosa-Associated Microbiome Across Gastroesophageal Reflux Disease Phenotypes

Biomedicines · 2026 · PMC13296020

Europe PMC
1
hedged sentence
0.0820
closest p · 1.6× alpha
0.0820
boldest claim

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did not reach statistical significancep = 0.082so close (0.05 < p ≤ 0.1)
In addition, we performed the sensitivity analysis using CLR-transformed non-rarefied data and Aitchison distance; the pattern of significance differed from the primary analysis: beta-diversity in the antrum site showed significant separation across GERD phenotypes (PERMANOVA, R 2 = 0.081, F = 1.42, p = 0.008), whereas beta-diversity in the duodenum site did not reach statistical significance (PERMANOVA, R 2 = 0.084, F = 1.24, p = 0.082).

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