Additionally, pharmacokinetic analysis showed that the area under the curve (AUC) was significantly higher in the NSPCC1-treated group than in the GSE-treated group ( Figure 1 F), whereas the maximum plasma concentration (Cmax) showed an increasing trend but did not differ significantly between these two groups ( Figure 1 G).
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Hematopoietic Rejuvenation via Natural Senolytic NSPCC1 Delays Inflammatory Aging.
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Colony-forming assays showed that irradiation reduced the total number of colonies formed by bone marrow cells, whereas NSPCC1 treatment partially restored colony-forming capacity, although the increase in total colony number did not reach statistical significance ( Figure 5 F).