Cholinergic Differentiation of Human iPSCs Reveals Early APOE4-Driven Dysregulation of Neuronal Markers, Synaptogenesis and Inflammatory Responses.

At the more mature stage, no significant changes were detected, although a slight trend toward decreased expression was observed.

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In APOE3 iNs after 4 days of differentiation, both genes were downregulated after 1 h of TNF-α treatment but showed a trend toward recovery, with no significant differences remaining after 4 h.

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