Continuous Topical Oxygen Therapy Is Associated with Accelerated Nipple–Areolar Complex Necrosis Healing Following Nipple-Sparing Mastectomy: A Propensity-Matched Three-Way Comparison

The model demonstrated good discrimination (C-statistic = 0.72) with no global proportional hazards violation, although the cTOT variable showed a marginally significant time-dependent effect (Schoenfeld P = 0.022), consistent with a front-loaded benefit that attenuates as wounds approach complete healing.

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The binary endpoint did not reach statistical significance, and the study was not powered for this outcome (post hoc estimated power 27%; approximately 230 patients per group would be required for 80% power).

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