Barely Significant
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Pharmacotherapeutic Options in Drug-Resistant Bipolar Depression: From Molecular Mechanisms to Rational Polypharmacotherapy

Biomedicines · 2026 · PMC13296849

2
hedged sentences
0.0870
closest p · 1.7× alpha
0.0870
boldest claim

The sentences

did not reach statistical significancep = 0.087so close (0.05 < p ≤ 0.1)
Despite a medium to large effect size (Cohen’s d = 0.72), this difference did not reach statistical significance ( p = 0.087), which the authors directly attribute to a lack of statistical power resulting from the premature termination of the study and recruitment due to the COVID-19 pandemic.

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highly significantno p-value reported
A highly significant indicator is the fact that 36% of patients achieved complete remission of depressive symptoms just 40 min after intravenous administration.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.