Ibandronate Use in Osteoporotic Vertebral Fractures: A Retrospective Clinical Study Integrated with Exploratory Network Pharmacology and Cross-Cohort Transcriptomic Analysis

Biomedicines · 2026 · PMC13297545

Europe PMC

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highly significantno p-value reported

A highly significant and predominantly same-direction DEG overlap was observed between GSE230665 and GSE35958 ; however, only one prioritized hub gene (MAPK1) met the predefined DEG threshold in both cohorts with the same direction of effect.

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did not reach statistical significanceno p-value reported

Ibandronate use was associated with numerically lower vertebral fracture occurrence, although this did not reach statistical significance in crude or adjusted analyses.

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