Fermented Dendrobium officinale Ameliorates Sleep Deprivation-Induced Depressive-like Behaviors by Attenuating Neuroinflammation and Restoring 5-HT Synthesis via the Gut–Brain Axis

After intervention with FDO or DO, the abundance of Bacteroidota decreased, whereas Firmicutes and Verrucomicrobiota showed an increasing trend, suggesting partial restoration of the SD-induced microbial community alteration.

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Both FDO and DO groups showed a certain reversal trend, although the effect in the DO group did not reach statistical significance ( Figure 5 D–F).

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