Inflammatory Cytokine Genetics and Coronary Artery Disease: Pathogenetic and Protective Analysis of IL-18 (−607 C/A, −137 G/C) and IL-8 (+781 C/T) Gene Variations

Curr Issues Mol Biol · 2026 · PMC13298403

Europe PMC

hedged sentence

0.0710

closest p · 1.4× alpha

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boldest claim

The sentences

did not reach statistical significancep = 0.071so close (0.05 < p ≤ 0.1)

Non-significant associations (clinical confounding): While the CC-CC and AA-CC combinations of IL-18 (−607)/IL-8 (+781) showed nominal significance in the univariate analysis, they did not reach statistical significance in the multivariate model (AOR = 2.65, 95% CI = 0.92–7.64, p = 0.071 and AOR = 2.88, 95% CI = 0.90–9.25, p = 0.075, respectively).

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