Effects of Different Doses of Ranolazine on SIRT1, APELA, and APL13 in a Rat MCAO Model

Curr Issues Mol Biol · 2026 · PMC13298514

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a decreasing trendno p-value reported

APL13 levels were lower in all ischemia-induced groups, with a decreasing trend observed as ranolazine dosage increased.

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did not reach statistical significanceno p-value reported

Regarding SIRT1, serum levels tended to decrease in the MCAO+RAN30 and MCAO+RAN50 groups and increase in the MCAO+RAN10 group compared with the Sham group; however, these differences did not reach statistical significance.

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