BAP1 and PBRM1 Loss Is Associated with Aggressive Clinicopathological Features in Clear Cell Renal Cell Carcinoma: Prognostic Implications in a 10-Year Surgical Cohort

Diagnostics (Basel) · 2026 · PMC13298600

Europe PMC

hedged sentences

0.0500

closest p · 1.0× alpha

0.4960

boldest claim

The sentences

borderline significancep = 0.050actually significant

Several histopathological parameters indicated a higher degree of biological aggression in the IHC-loss group: Tumor Necrosis: Microscopic coagulative necrosis was detected in 7 of 19 IHC-loss tumors (36.8%), whereas it was present in 36 of 195 wild-type tumors (18.5%) ( p = 0.050; borderline significance).

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did not reach statistical significancep = 0.496not close (p > 0.1)

26 of 38 [68.4%]); however, this difference did not reach statistical significance ( p = 0.496). 3.7.

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