Event rates in major Phase 3 heart failure trials over the last 20 years.

ESC Heart Fail · 2026 · PMC13298876 · PMID 42275607

Europe PMC DOI

hedged sentence

0.0730

closest p · 1.5× alpha

0.0730

boldest claim

The sentences

a clear trendP = .073so close (0.05 < p ≤ 0.1)

For cardiovascular mortality, no single predictor reached P < .05; however, trials requiring NYHA III–IV at entry showed a clear trend towards higher CV death rates (β = +.064; P = .073; Δ R 2 = .143).

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