HSV-2 gC2 mRNA immunization in mice protects by producing antibodies that bind immune evasion epitopes

Day 4 vaginal swab titers and HSV-2 DNA copy number in dorsal root ganglia (DRG) were significantly lower in the animals that received H1196 and LH17b than in non-immune IgG animals, while differences between gC2 3E2B5 and non-immune IgG did not reach statistical significance ( Fig 7E-7G ).

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We detected highly significant increases in endpoint titers from doses 0.25-10 μg after the first (I) and second (II) immunization with no further increase after the third (III) ( Fig 3B ).

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