Blood-Based Epigenetic Aging Signatures in D3GHR Carriers: An Exploratory Pilot Study of Metabolic Adaptation and Aging-Related Pathways

Int J Mol Sci · 2026 · PMC13299114

Europe PMC

hedged sentences

0.0558

closest p · 1.1× alpha

0.0558

boldest claim

The sentences

a trend toward significancep ≈ 0.0558so close (0.05 < p ≤ 0.1)

The Skin & Blood clock also showed no statistically significant genotype effect, although AARs exhibited a trend toward significance (ANOVA p ≈ 0.0558).

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showed a trendno p-value reported

Consistent with this interpretation, PhenoAge, which is calibrated to physiological dysregulation and mortality risk, showed a trend toward epigenetic deceleration, aligning more closely with the reported longevity-related phenotype [ 16 ].

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