Early Combined B-Cell Depletion and BTK Inhibition Reduced TLS-like Structures and Relapse in PLP139–151-Induced EAE

Flow cytometry analysis of microglia extracted from the brain showed a decreasing trend in the proportion of pro-inflammatory CD86 + microglia in the late combination therapy group, whereas the percentage of anti-inflammatory CD206 + microglia did not show a significant difference ( Figure 7 I,J). 3.

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However, the outcome was surprising; this approach not only failed to suppress disease relapse but showed a trend toward exacerbating relapse severity.

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