Phytochemical Profile, Antioxidant Activity, and Neuroprotective Effects of Bacopa monnieri Extract in a Lipopolysaccharide-Induced Dementia Model

There was a highly significant main effect of training day on both escape latency (F(3, 72) = 58.61, p < 0.001, η 2 p = 0.71; Greenhouse–Geisser corrected) and path length (F(3, 72) = 85.92, p < 0.001, η 2 p = 0.78; Figure 4 A,B), indicating that all groups, including the LPS-induced model group, acquired the task across the training period.

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RVS, the positive control, differed significantly from the LPS group on path length on day 1 (mean difference 403 cm, p = 0.021, g = 1.94) and day 4 (mean difference 251 cm, p = 0.004, g = 2.19), and showed near-significant separation from the LPS group on day 4 escape latency ( p = 0.057).

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