Domain-Level Distribution of Pathogenic BRCA1/2 Somatic Mutations Shows No Evidence of Large Subtype-Specific Enrichment in Breast Cancer: A Three-Cohort Analysis Supporting Broad BRCA Testing.

Genes (Basel) · 2026 · PMC13299929 · PMID 42353852

Europe PMC DOI

hedged sentence

0.3600

closest p · 7.2× alpha

0.3600

boldest claim

The sentences

a numerical trendp = 0.36not close (p > 0.1)

did not reach statistical significanceno p-value reported

The DBD, which contains the principal DNA-binding apparatus essential for RAD51-mediated HR, demonstrated a numerical trend toward higher representation in HR+/HER2− (30.8%, 16/52) than TNBC (17.6%, 3/17; OR = 0.48, raw p = 0.36; and FDR-adjusted p = 1.00); however, this did not reach statistical significance.

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