In Vivo ORF Overexpression Screening Identifies CCN4 as a Regulator of Glioblastoma Growth Validated Across Multiple Models

Int J Mol Sci · 2026 · PMC13299954

Europe PMC

hedged sentence

0.2400

closest p · 4.8× alpha

0.2400

boldest claim

The sentences

did not reach statistical significancep = 0.24not close (p > 0.1)

Patients with higher expression of CHRAC1 and PSCA demonstrated a trend toward worse overall survival; however, this difference did not reach statistical significance ( p = 0.24, p = 0.16, respectively), likely reflecting limited cohort size ( Supplemental Figure S1D,E ).

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