Integrative Transcriptomic Analysis and Single-Cell Validation Identify a Six-Hub-Gene Signature Converging on Inflammatory Signaling in Osteoarthritis.

Genes (Basel) · 2026 · PMC13300059 · PMID 42353855

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Gene set enrichment analysis (GSEA) independently corroborated these findings: Epithelial–Mesenchymal Transition (EMT) was positively enriched ( Figure 2 D), while “Apoptosis” showed a trend toward negative enrichment ( Figure 2 E).

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