Antibody-Drug Conjugates in Solid Tumor Oncology and the Frontier of Precision Immunosuppression: A Mechanistic, Translational, and Clinical Review

Int J Mol Sci · 2026 · PMC13300373

Europe PMC

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did not reach statistical significanceno p-value reported

Median overall survival was numerically higher with datopotamab deruxtecan but did not reach statistical significance in either the overall population or the prespecified non-squamous subgroup, illustrating the importance of histologic context in TROP2-targeted therapy [ 90 ].

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