Semaglutide Selectively Improves Metabolic and Cognitive Function in 5xFAD Mice

Int J Mol Sci · 2026 · PMC13300714

Europe PMC

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an increasing trendno p-value reported

SMGL treatment elevated leptin concentrations in HFD-treated WT mice specifically, as well as an increasing trend in 5xFAD HFD post-SMGL treatment, although this was not significant.

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did not reach statistical significanceno p-value reported

The other groups showed a downward trend in AUC post-treatment, although these differences did not reach statistical significance post-treatment.

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