Efficacy and Safety of PD-1 Inhibitor-Based Regimens in Patients with Melanoma: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

J Clin Med · 2026 · PMC13300751

Europe PMC

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did not reach statistical significanceno p-value reported

Nivolumab plus ipilimumab showed trends toward improved OS, although the analysis did not reach statistical significance (HR = 0.85, 95% CI: 0.62–1.17) ( Figure 2 ).

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