Effect of a Prior Two-Hour Postural Test on Seated Saline Suppression Test Results in Patients Predominantly Evaluated for Adrenal Incidentalomas

There was a significant increase in aldosterone and renin concentrations following a 120 min period of an upright posture (i.e., standing or sitting position), p < 0.0001; however, an overall suppression of aldosterone secretion was either not different after the first protocol versus the second protocol (6.34 ± 0.68 ng/dL (mean ± SEM) versus 5.74 ± 0.66 ng/dL, p = 0.124 (Mann–Whitney U test)) or showed a trend towards slightly lower values ( p = 0.08 for Wilcoxon test (mean ± SEM)).

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