Enhanced Osteogenic Differentiation of Primary Human Osteoporotic Osteoblasts on a Roughened Titanium Surface by Vitamin K2 and Vitamin D3 Compared to the Differentiation Behaviour of Primary Healthy Human Osteoblasts.

Although the long-term observation of mineralisation showed a significantly higher incidence of this in hopOBs compared to hOBs ( Figure 4 D), a clear trend was not observed in the differentiation.

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This also applied to the addition of vitamin K2 for long-term observation of differentiation, whereby the difference proved to be highly significant.

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