Is Fibrin a Suitable Matrix for Small-Diameter Bioartificial Vascular Grafts? An In Vitro Short-Term Hemocompatibility Study.

While the tendency towards higher activation of the plasmatic coagulation in fibrin-based grafts did not reach statistical significance compared to the heparinized synthetic grafts, and the clinical implications of residual soluble thrombin in the larger blood volume of the human circulatory system remain unclear, possible measures in future approaches could include more intense washing and rinsing of the grafts after polymerization to eliminate residual thrombin.

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