FIB-4 Index as a Non-Invasive Biomarker of Congestion and Prognosis in Heart Failure.

J Clin Med · 2026 · PMC13302568 · PMID 42355616

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did not reach statistical significanceno p-value reported

A 2025 meta-analysis of 25 RCTs ( n = 2600) confirmed that Glucagon-like Peptide-1 Receptor Agonist (GLP-1RAs) significantly reduce liver fat, aminotransferases, and liver stiffness, although class-level histological improvement in fibrosis did not reach statistical significance—evidence of the benefit on fibrosis was stronger for semaglutide and tirzepatide when considered individually [ 57 ].

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