The Effectiveness of Methylene Blue in Adult Shock: A Systematic Review, Meta-Analysis, and Trial Sequential Analysis of Randomized Controlled Trials.

J Clin Med · 2026 · PMC13302755 · PMID 42355649

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did not reach statistical significanceno p-value reported

The pooled OR for 28–30-day mortality was 0.73 (95% CI 0.40–1.36), indicating a directional trend favoring MB that did not reach statistical significance.

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