Barely Significant
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Effect of Perioperative Ketamine and Esketamine on Postoperative Fatigue: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Medicina (Kaunas) · 2026 · PMC13303731 · PMID 42356168

Europe PMCDOI
1
hedged sentence
0.0698
closest p · 1.4× alpha
0.0698
boldest claim

The sentences

did not reach statistical significancep = 0.0698so close (0.05 < p ≤ 0.1)
Both bolus plus infusion (SMD −0.42, 95% CI −0.66 to −0.18) and bolus-only regimens (SMD −0.91, 95% CI −1.39 to −0.44) were associated with significant reductions in fatigue ( Figure 4 c), although the difference between regimens did not reach statistical significance ( p = 0.0698).

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